введение       научных публикаций       продукты       тесты       руководство       qvive online       обратная связь

 Контакты    Заказать    Бесплатные Демо

Qvive предлагает вам возможность контролировать эффекты любой стратегии здравоохранения.

    Qvive базирован на компьютерных анализах вариабельности сердечного ритма, ЭКГ.
    Qvive использовать легко во всех сферах медицины.
    Qvive является результатом тридцатилетних углубленных научных исследований.

Qvive состоит в нескольких тестов для анализа состояния здоровья:

    Стресс-Тест  Фитнес-Тест  Риск Здоровья  ЭКГ Анализ  Автономный Баланс


 Materials & Methods
 Results & Discussion

S. Danev , E. Datzov , S. Svetoslavov

Spontaneous variability of blood pressure and R-R interval time can be expressed by its standard deviation.However, this measure does not give reliable information about the real source of these fluctuations.Spectral and cross spectral analyses are more informative, as has been shown for the analysis of heart rate variability [1] and for the relationship between the variations in heart rate and blood pressure [2]. It is a well established fact, that oscillations in the activity of brain centers regulating blood pressure, respiration and body temperature are reflected by heart rate, and consequently by the frequency spectrum of heart rhythm [3-7]. Independent study of heart rate and blood pressure variations is less informative than the assessment of their reciprocal correlation by comparison of their frequency spectra (coherence) [2].
The main purpose of the study was to assess the drift in autonomic equilibrium by spectral amplitude coherence and phase of R-R intervals and blood pressure spectra. The sympathetic effect was achieved by Atropine administration, as typical antimuscarinic agent. The sympathicolytic effect was achieved by Obsidan administration.


The study was conducted in two sequential phases 1) administration of oral dose of Atropine (1 amp. 0.1 %, 1 ml two consecutive days) required to produce sympathetic effect and 2) the oral uptake of Obsidan (3x1 tabl. 25 mg first day, 1 tabl. second day) required to produce beta-adrenergetic blocade (decrease of the overal sympathetic tone and of the heart inotropic function).


Twelve practically healthy female students aged 19-25 years (mean age 22.1 years) were studied. Measurement was performed at rest in a quiet room for a period of 10 minutes. Every subject was measuring three times: before administration, in the first day and in the second day after Atropine or Obsidan administration. Beat-to-beat blood pressure (BP) and R-R intervals (RRI) were obtained noninvasively by plethysmographic signal from the left middle finger of the hand (diagnostic polyphysiographical complex KTD-8). A procedure similar to this proposed by Penaz [8] was used. The finger arterial - pressure signal, sampled at 200 Hz, was digitally lowpass filtered by a five point rectangular moving average filter, and down-sampled to 100 Hz. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) values were determined as maximums and minimums of consecutive plethysmographic waves. The RRI were also derived from the plethysmographic signal ( the times between two successive systolic upstrokes of the pressure signal ). Power spectra of the areas under the spectral curve between 0.01 Hz - 0.5 Hz were calculated from these beat-to-beat values, using a Digital Fourier Transform. In order to assure of better visual control of the recording`s quality the RRI and BP were displayed on a monitor. Pearson correlation coefficients were employed for data comparison. Artefact correction based on an interpolation algorithm was also provided.The relationship between fluctuations in SBP, DBP and corresponding changes in RRI time was expressed in terms of spectral amplitude coherence and phase. The amplitude coherence is equivalent to the variance in a linear regression analysis. The phase represents the time delay (in seconds) between the signals in the zone of the biggest coherence. Coherence was calculated by variation analysis of the amplitude and phase characteristics of the obtained cross spectra. The amplitude correlation coefficients were calculated for the spectral frequencies 0.01 Hz - 0.5 Hz .


The effect of oral administration of Atropine and Obsidan on correlation coefficients in amplitude coherence cross spectra (ACCS) of RRI and BP are shown on Table 1. Statistical analysis revealed a significant decrease of correlation coefficients in ACCS of RRI to SBP and RRI to DBP comparing before and after Atropine administration (P < 0.05).="" there="" exists="" also="" a="" significant="" increase="" of="" correlation="" coefficients="" in="" accs="" of="" rri="" to="" sbp="" (p="">< 0.05)="" and="" rri="" to="" dbp="" (p="">< 0.01)="" comparing="" before="" and="" after="" obsidan="" administration.="" the="" accs="" between="" rri="" and="" sbp="" in="" a="" healthy="" female="" person="" before="" and="" after="" atropine="" and="" obsidan="" administration="" are="" shown="" on="" fig.="">
There were not observed statistically significant phase differences in cross spectra of RRI and BP comparing before and after Atropine or Obsidan administration .
The present study shows that low doses of oral Atropine (blocking of "N" holinoreceptors of postsynaptic membrane) are decreasing the vagal influence upon RRI and BP fluctuations whereas low doses of Obsidan (blocking of beta-adrenoreceptors) are decreasing the sympathetical influence upon RRI and BP fluctuations.This was reflected by the ACCS between RRI and BP which is supporting the idea to use frequency domain measures of RRI and BP and their relationships as an objective criterion for assessment of different physiological phenomena involving autonomic disequilibrium as: work-related stress, fatigue, deterioration in common functional state, effect of pharmacological treatments, control in the area of alternative medical practice etc. [9]. The mathematical algorithm for computing RRI and BP variables developed by us is proposed to the scientists dealing with such a kind of problems.


[1] Mulder G., L. J. M. Mulder. Psychophysiol., 14, 1981, 392-402.
[2] Mulder L. J. M.. In: The psychophysiology of cardiovascular control. (Eds J. F. Orlebeke, G. Mulder and L. P. J. van Doornen). N. Y., Plenum Press, 1985, 333-352.
[3] Berger R. D., S. Akselrod, D. Gordon, R. Cohen. IEEE. Trans. Biomed. Eng., 9, 1986, 900-906.
[4] Kleiger R. E., I. T. Bigger, M. S. Bosner, M. K. Chung, I. R. Cook, L. M. Rolnitzky, R. Steinman, I. L. Fleiss. Am. J. Cardiol., 68, 1991, 626-631.
[5] Stein P. K., M. S. Bosner, R. E. Kleiger, B. M. Conger. Am. Heart J., 127, 1994, 1376-1382.
[6] Herpin D., R. Asmar et al. J. of Hypertens., 13, 1995, 1654-1659.
[7] Huikuri H., A. Ylitalo, S. Pikkujamsa, M. Ikaheimo, J. Airaksinen, A. Rantala, M. Lilja, A. Kesaniemi. Am. J. Cardiol., 77, 1996, 1073-1077.
[8] Penaz J..In: Photo-electric measurement of blood pressure, volume and flow in the finger. (Eds. R. Albert, W. Vogt and W. Helbig). Dig. of the 10-th Int. conf. on med. and biol. eng., Dresden, 1973, 104-111.
[9] Datzov E., S. Danev, S. Svetoslavov. Acta Med. Bulg., 1997, 1.

National Center of Hygiene, Medical Ecology and Nutrition D. Nestorov Blv., N 15 1431 Sofia, Bulgaria

Table 1
Mean values ( SD ) of correlation coefficients of amplitude coherence cross spectra in "Atropine" and "Obsidan" experimental conditions in twelve female persons.

Cross spectrum

Before administration

After Atropine administration

After Obsidan administration


� 0.78


� 0.70*


� 0.88*



� 0.76


� 0.67*


� 0.92**


RRI - R-R intervals; SBP - systolic blood pressure; DBP - diastolic blood pressure.
*P < 0.05;="" **p=""><>

Before administration

After Atropine administration

After Obsidan administration

Fig. 1. Amplitude coherence cross spectra between R-R intervals and systolic blood pressure in a healthy 23 years old female person with manipulated vagal to sympathetical equilibrium by provoking sympathetic effect (Atropine administration) and sympathicolytic effect (Obsidan administration).

home   |   введение   |   научных публикаций   |   продукты   |   тесты   |   руководство   |   qvive online   |   english
стресс-тест   |   фитнес-тест   |   риск здоровья   |   экг анализ   |   автономный баланс   |   скорости пульсовой волны
обратная связь   |   контакты   |   заказать   |   бесплатные демо

All company names, product names logos included here may be registered trademarks or service marks of their respective owners.

1408-208 Queens Quay w., Toronto, ON, Canada M5J 2Y5, Tel: +1 416 566 6592, Fax: +1 416 901 7732
Copyright © 1999-2007 Medeia. All Rights Reserved.

купить гидравлическую тележку в москве